Structural Studies of Human 7s Γ-globulin (g Immunoglobulin)

Two Major Types of Normal 7s Γ-globulin

Normal 7S human gamma-globulin was found to contain two fundamental antigenic groups of molecules. The group 1 molecules of normal gammaglobulin correspond antigenically to group 1 multiple myeloma proteins and Bence Jones proteins; and group 2 molecules of normal gamma-globulin correspond antigenically to group 2 multiple myeloma proteins and Bence-Jones proteins. Among pooled human Fr II and ...

Studies on Structural Units of the Γ-globulins

When human and rabbit 7S gamma-globulins were reduced in strong urea solutions by a number of procedures, their molecular weights fell to approximately (1/3) of the original values. Partial separation of the reduction products was achieved using chromatography and starch gel electrophoresis in urea solutions. One of the components of reduced human 7S gamma-globulin was isolated by chromatograph...

The Immunoglobulins of Mice

Two classes of 7S gamma-globulins are identified in normal mouse serum and are designated 7S gamma(2)-globulins and 7S gamma(1)-globulins. These two immunoglobulin classes are similar in size. They differ in range of electrophoretic mobility, in specific antigenic determinants, and in genetically determined isoantigens. Four classes of immunoglobulins in mouse serum, i.e. 7S gamma(2)-, 7S gamma...

Structural units of human 7S gamma globulin.

Normal counterparts to Bence-Jones proteins: free L polypeptide chains of human gamma-globulin.

Bence-Jones proteins are commonly found in patients with multiple myeloma and have been defined classically' as abnormal urinary proteins that have characteristic thermosolubility properties. Structural studies2 have shown that BenceJones proteins are similar or identical to the light (L) polypeptide chains isolated from the myeloma globulin of the same patient. Taken in conjunction with the re...